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Meeting # 942 7359 5552

Zoom Meeting # 942 7359 5552

Abstract:

Heart attacks and strokes cause 1/3 of death in the modern world, which stem from a process called arterial thrombosis where clot forms abruptly in a narrowed artery obstructing blood flow. Current anti-thrombotic pharmaceuticals targeting biochemistry remain largely ineffective while leading to excessive bleeding risks. Our recent studies have led to evidence showing thrombosis is primarily controlled by a biophysical process of cells and proteins aggregating through high-shear hemodynamics. Decoding the biophysical mechanisms of arterial thrombosis in multiscale can lead to novel preventive strategies for successful longevity. In this colloquium talk, I will cover how we develop multiscale computational models suitable for driving first-principle based understanding of arterial thrombosis at multiple scales spanning from molecular, cellular to tissue levels. I will show how we combine multiscale computation as well as AI on in silico supercomputing chips and whole blood experiments on in vitro fluidic chips to form a powerful engine to drive scientific discovery. I will also discuss how novel treatment, and potential medical devices may be inspired from the unconventional biophysics predicted by our in silico and in vitro models.

Speaker's Bio

Dr. Leo Liu is an Assistant Professor of Chemical and Biomedical Engineering at the FAMU-FSU College of Engineering since Fall 2022. He earned his Ph.D. in Mechanical Engineering (minor in Computational Science and Engineering) from Georgia Tech in 2021. He was a Postdoctoral Fellow of Applied Mathematics at Brown in 2022. He was a visiting scholar at Sandia National Laboratories in 2018. He currently directs the Group for Living Fluids (GoLF) that combines advanced computational and experimental approaches to unravel the biophysical mechanisms of heart attacks and strokes. His research impacts the field of biofluid mechanics and helps guide bioengineered solutions to heart attacks and strokes. He is the recipient of numerous awards, including First-Year Assistant Professor (FYAP) Award at FSU (2023), State-of-the-Art (SOA) Lectureship through the International Society on Thrombosis & Hemostasis (2024), and the Eberhard F. Mammen Young Investigator Award (YIA) for research excellence in thrombosis & hemostasis (2025). His research group is currently funded by Sandia National Laboratories. The computing resources are funded by NSF ACCESS program.

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